XE 991 dihydrochloride
CAS No. 122955-13-9
XE 991 dihydrochloride ( XE-991;XE991 )
产品货号. M10900 CAS No. 122955-13-9
A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥786 | 有现货 |
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10MG | ¥1256 | 有现货 |
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25MG | ¥2406 | 有现货 |
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50MG | ¥4447 | 有现货 |
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100MG | ¥6448 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称XE 991 dihydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
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产品描述A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM, enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.Alzheimer Disease Discontinued
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同义词XE-991;XE991
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Potassium Channel
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number122955-13-9
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分子量449.37
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分子式C26H20N2O.2HCl
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
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化学全称10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
产品手册
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