• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

XE 991 dihydrochloride

CAS No. 122955-13-9

XE 991 dihydrochloride ( XE-991;XE991 )

产品货号. M10900 CAS No. 122955-13-9

A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥786 有现货
10MG ¥1256 有现货
25MG ¥2406 有现货
50MG ¥4447 有现货
100MG ¥6448 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    XE 991 dihydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
  • 产品描述
    A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM, enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.Alzheimer Disease Discontinued
  • 同义词
    XE-991;XE991
  • 通路
    Cell Cycle/DNA Damage
  • 靶点
    Potassium Channel
  • 受体
    Potassium Channel
  • 研究领域
    Neurological Disease
  • 适应症
    Alzheimer Disease

化学信息

  • CAS Number
    122955-13-9
  • 分子量
    449.37
  • 分子式
    C26H20N2O.2HCl
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
  • 化学全称
    10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
产品手册
关联产品
  • Chlorzoxazone

    Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.

  • Potassium Channel Ac...

    Potassium Channel Activator 1 can be used in studies about the treatment of disorders or conditions wherein the dopaminergic system is disrupted such as mood disorders ADHD, schizophrenia, and other psychotic states.

  • VU0810464

    VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK Kir3) activator.